PS Nutrition S23 10mg

S23 has become increasingly popular in the recreational bodybuilding community for its potent muscle building and body recomposition effects.

• Promotes lasting muscle mass
• Reduces fat mass
• Improves libido in men and women
• No bloating or fluid retention

S23 is used to achieve a chiseled, hardened look that is sought after in bodybuilding competitions. A popular strategy is to add S23 near the end of the training cycle to achieve a competitive physique. PCT s highly recommended after the cycle of S23. As with many other SARMs , we also recommend to do your own research about this compound.

Nutrition Information

Servings: 100

S23 10mg per serving 10

More about S23

S23 is being called the strongest SARM available on the market. This is not supported by research

Ostarine and LGD-4033 are also popular high-powered SARMs for bodybuilding. Cell studies show S23 has a higher binding strength than Ostarine and a similar binding strength to LGD-4033. However, other factors play into their strength and more studies are needed for a reliable comparison.

S23 in particular was shown to maintain the anabolic activity in muscle tissue equivalent to therapeutic levels of Testosterone at 0.1 mg per day in rats, while only stimulating prostate size up to 30% of an intact control rat (a healthy non-castrated rat with normal Testosterone/DHT levels) [R].

Anecdotally, S23 is one of the most side effect ridden SARMs of all due to its high level of androgenic activity relative to other SARMs.

S23 has a very high binding affinity for the androgen receptor (AR) with a K_i of ∼1.7 nM [R].

The structural modification of C-6 didn’t just increase S23’s oral bioavailability, it also increased its AR binding affinity two times higher than that of C-6, which has a K_i of ∼4.9 nM.

To put this in perspective, RAD140 demonstrated excellent affinity for the androgen receptor with a K_i of 7 nM [R].

S23 has a binding affinity over four times higher than RAD140, which was already considered impressive.

The binding affinity of Testosterone and DHT remains unclear as each study seems to render significantly different values.

In the RAD140 study the affinity for the androgen receptor for Testosterone was 29 nM, and 10 nM for DHT.

In the study conducted on S23, DHT was stated to have a K_i of 0.45 nM.

The only SARM that has been trialed on humans and isn’t still in the preclinical stage that is reported to have a formidable binding affinity to S23 is LGD-4033, which has a Ki of ∼1 nM [R].